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49ers' Jennings, Williams Active for Saints Game, But Purdy, Kittle Out Amid Major Week 2 NFL Injuries

Published on: 14 September 2025

49ers' Jennings, Williams Active for Saints Game, But Purdy, Kittle Out Amid Major Week 2 NFL Injuries

49ers Injury Updates: Jauan Jennings, Trent Williams Active; Purdy Out Against Saints

The San Francisco 49ers will have wide receiver Jauan Jennings and left tackle Trent Williams available for their Week 2 game against the New Orleans Saints. However, starting quarterback Brock Purdy will be sidelined due to shoulder and toe injuries.

Jennings and Williams Clear to Play

Both Jennings and Williams were listed as questionable leading up to the game. Jennings was dealing with a left shoulder injury sustained during the 49ers' Week 1 victory over the Seattle Seahawks, while Williams was managing a knee injury. Scans on Jennings' shoulder came back clean, indicating he avoided serious damage. Williams tested his knee during pre-game warmups and was cleared to play.

Purdy Out, Kittle on Injured Reserve

The 49ers will be without Brock Purdy, who is dealing with left shoulder and toe injuries. Furthermore, tight end George Kittle was placed on injured reserve Tuesday because of a hamstring injury, further impacting the team's offensive options.

Purdy's Return Timeline Uncertain

The 49ers are not optimistic that Purdy will be ready for Week 3 against the Arizona Cardinals. Coach Kyle Shanahan and General Manager John Lynch previously indicated that Purdy's injury was considered week-to-week. "We'll see for next week," a source said about Purdy. "Next week will be tight, but he progressed a lot this week." FOX NFL Insider Jay Glazer suggests Purdy's timeline could be 1-3 weeks.

Week 2 NFL Injury Report: Key Players In and Out

Several other key players across the NFL are dealing with injuries in Week 2. The New York Giants' wide receiver, Malik Nabers, is managing a back injury but is expected to play. Other notable injuries include Cincinnati Bengals quarterback Joe Burrow, who exited his game with a toe injury, and Buffalo Bills quarterback Josh Allen, who briefly left his game with a nose injury, but later returned.

Player Team Injury Status
Brock Purdy 49ers Left Shoulder, Toe Inactive
Jauan Jennings 49ers Shoulder Active
Trent Williams 49ers Knee Active
Malik Nabers Giants Back Active
Andrew Thomas Giants Foot Inactive
Joe Burrow Bengals Toe Questionable (Week 2 game)
Josh Allen Bills Nose Returned (Week 2 game)
Devon Witherspoon Seahawks Knee Inactive
Christian Gonzalez Patriots Hamstring Inactive
Jaylen Waddle Dolphins Shoulder Active

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